hollow core fibers can increase the throughput of analyzed particles
nanoparticle tracking analysis in hollow core fibers instead of in hollow optical fiber can increase the throughput of the measured particles[@Fo2020Tracking and Analyzing the Brownian Motion of Nano-objects Inside Hollow Core Fibers]. However, hollow core fibers have the same problem of free diffusing particles that go out of focus or overlap each other's trajectories. On a typical experiment [@Fo2020Tracking and Analyzing the Brownian Motion of Nano-objects Inside Hollow Core Fibers], it is possible just 100 particles and not all of them for sufficiently long times even if they were using non-diluted samples.
The number of particles that can be measured in parallel is more than one order of magnitude higher than in previous reports about tracking in optofluidic fibers. [@Fo2020Tracking and Analyzing the Brownian Motion of Nano-objects Inside Hollow Core Fibers]
Considering that in hollow optical fibers it is possible to track 100's of particles, I wonder how would a hollow core fiber would actually increase the throughput of the method beyond what free diffusion offers. See: limitations of nanoparticle tracking analysis
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