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Hollow core fibers can increase the throughput of analyzed particles

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nanoparticle tracking analysis in hollow core fibers instead of in hollow optical fiber can increase the throughput of the measured particles[@Fo2020Tracking and Analyzing the Brownian Motion of Nano-objects Inside Hollow Core Fibers]. However, hollow core fibers have the same problem of free diffusing particles that go out of focus or overlap each other's trajectories. On a typical experiment [@Fo2020Tracking and Analyzing the Brownian Motion of Nano-objects Inside Hollow Core Fibers], it is possible just 100 particles and not all of them for sufficiently long times even if they were using non-diluted samples.

The number of particles that can be measured in parallel is more than one order of magnitude higher than in previous reports about tracking in optofluidic fibers. [@Fo2020Tracking and Analyzing the Brownian Motion of Nano-objects Inside Hollow Core Fibers]

Considering that in hollow optical fibers it is possible to track 100's of particles, I wonder how would a hollow core fiber would actually increase the throughput of the method beyond what free diffusion offers. See: limitations of nanoparticle tracking analysis

See: 202010261540

Tags: #nanoparticle-tracking-in-channels


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