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Extracellular vesicles as markers for prostate cancer

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Extracelluar vesicles can be used as markers for prostate cancer. The general idea is that patients with cancer will have a higher abundance of exosomes with CD9 and CD63, therefore if it would be possible to quantify the amount of these proteins, they would become a clear path to diagnosis.

One possible path is to combine TR-FIA with europium labeling[@duijvesz2015aImmuno-based detection of extracellular vesicles in urine as diagnostic marker for prostate cancer: Extracellular vesicles as marker for PCa]. An essay similar to Elisa tests with fluorescence is able to quantify the amount of CD9 and CD63 in urine samples from patients with and without prostate cancer.

Europium-based detection of CD9 and CD63 in urine samples

The overall idea is that quantifying the concentration of CD9 and CD63, it is possible to have a better diagnostic tool than by just looking at PSA levels.


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